EFFICACY AND TOLERABILITY OF TWO QUADRUPLE REGIMENS: BISMUTH, OMEPRAZOLE, METRONIDAZOLE WITH AMOXICILLIN OR TETRACYCLINE AS FIRST-LINE TREATMENT FOR ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER: A RANDOMIZED CLINICAL TRIAL.

Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulcer: A Randomized Clinical Trial.

AimTo evaluate the efficacy and tolerability of tetracycline vs.high-dose amoxicillin in bismuth-based quadruple therapy for Helicobacter pylori(H.pylori) eradication.MethodsThis randomized, open-label clinical trial included 228 patients with H.pylori infection and duodenal ulcer without a history of H.pylori treatment.Patients were randomly divid

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Physiological Roles of DNA Double-Strand Breaks

Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike.Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix.Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these proc

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